Synthesis and antimicrobial activities of benzothiophene. Thiophene is ppt on a modest synthesis of around alkylthiols to provide thiophene trifluoroborates in high pdf with. Pdf converter is a online webbased document to pdf converter software. Photochemical oxidation of benzothiophene in seawater. No file size restrictions, no ad watermarks just a free online tool for creating pdfs from your ppt slides. In the powerpoint preferences dialog box, click general. A palladiumcatalyzed ch arylation of electronenriched heteroarenes with aryl bromides and aryl chlorides. Photocatalytic degradation of benzothiophene and dibenzothiophene using supported gold nanoparticle article pdf available in journal of saudi chemical society 2 november 2016 with 8 reads.
Benzothiophenes heterocyclic building blocks sigmaaldrich. The effects of reaction conditions such as the reaction medium ph, solvent type, and adsorbent on the reactivity of ferratevi with the thiophenecontaining compounds were investigated. The developed synthetic method couples aryl or heteroaryl bromides with thiophenes bearing electrondonating or electronwithdrawing groups and other heterocyclic moieties such as benzothiophene, benzofuran, and pyrrole with very good yields. Jul 01, 20 synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Download as ppt, pdf, txt or read online from scribd. It occurs naturally as a constituent of petroleumrelated deposits such as lignite tar. Benzothiophenes, an important class of heterocycles, are privileged structures, used as starting materials for the synthesis of bioactive structures, and are present in pharmaceuticals. Bioactivation potential of thiophenecontaining drugs. Learning outcomes by the end of the lecture, students will be able to 1. Synthesis of benzothiophene and indole derivatives through. Penthala nr1, sonar vn, horn j, leggas m, yadlapalli js, crooks pa. In a 3month study, arzoxifene prevented estrogendeficiencyinduced bone loss in ovariectomized ovx rats 16.
To construct more desirable adsorption affinity between the current metalorganic frameworks and benzothiophene bt, a novel desulfurizer vcubtc, where btc represents 1,3,5benzenetricarboxylic acid was prepared by reducing cuii to cui with viii on cubtc using a. General read this before lecture 3 thiophenes and pyrroles are also extremely important compounds vital for the chemistry of. Ramendra pratap, in the chemistry of heterocycles, 2019. Thiophene soxides and thiophene epoxides are highly reactive electrophilic thiophene metabolites whose formation is cytochrome p450dependent. Antiinflammatory and analgesic benzothiophene and benzafuran. An interrupted pummerer reaction between benzothiophene s. Organic chemistry program of study committee william s. Desulfurization increases with grinding to finer sizes and with decreasing density of separating medium. Synthesis of 1benzothieno3,2b1benzothiophene derivatives via. Mar 12, 2018 an interrupted pummerer reaction between benzothiophene s. Biodesulfurization of benzothiophene and dibenzothiophene.
The pyrite rejection is dependent to the particle size distribution of pyrite. The word indoles derived from the word india blue dye. Benzothiophene manufacturer, benzothiophene suppliers. Synthesis and evaluation of a series of benzothiophene. Snar occurs readily on benzothiophenes, but they have some strange reactions with. Figure 2 is a new benzothiophene analog that is structurally related to raloxifene. Gib deine fertiggestellte powerpointprasentation in einem flexibleren dateiformat aus. Tse424 is an oral, nonsteroidal, indolebased serm being developed for the prevention and treatment of osteoporosis. Very small and highly disseminated pyrite particles are nearly impoosible to separate from coal. Benzothiophene is regarded as a privileged class of structure showing a wide spectrum of biological activities. Sales training role of atp atp adenosine tri phosphate. Pages in category benzothiophenes the following 16 pages are in this category, out of 16 total.
It is considered to be a structural alert, as its metabolism can lead to the formation of reactive metabolites. Synthesis of c2 substituted benzothiophenes via an. Save powerpoint presentations as pdf files office support. Novel benzofuranbenzothiopheneincorporated triphyrins2. Schematic presentation of the configuration used in the validation. Full paper results and discussion previously, we reported on synthetic methodologies for the preparation of thieno2,3dpyrimidinebased bisphosphonate10 and monosphosphonate thpmps11 libraries of com pounds with the ability to inhibit isoprenoid biosynthesis. Medicinal chemistry heterocyclic compounds free download as powerpoint presentation. It is used in organic as well as pharmaceutical industry as a component in the synthesis of raloxifene, a breast cancer therapeutic, or hydrodesulfurization reactions. Benzothiophene is an aromatic organic compound with a molecular formula c8h6s and an. The photooxidation of benzothiophene followed the first order reaction law, with the rate constants ranging from 1. Ppt thiophene powerpoint presentation free to view id.
Gc and gcms analyses revealed that strain kt462 has the same bt desulfurization pathway as that reported for paenibacillus sp. Visible light photocatalytic synthesis of benzothiophenes organic. Benzothiophene article about benzothiophene by the free. Benzobthiophene is used in the preparation of 2thianapthenylphenyllithium, via metalation by nbutyllithium. The tbt, prepared by fusing thiophene unit with the phenyl unit of triphenylamine donor, is utilized as the bridge for all sensitizers with good. Make ppt and pptx slideshows easy to view by converting them to pdf. Structurally important biarylthioether, benzobthiophenes, and thieno3,2b thiophene scaffolds are provided in high yield. A mechanistic study of photochemical deoxygenation by mrinmoy nag a dissertation submitted to the graduate faculty in partial fulfillment of the requirements for the degree of doctor of philosophy major. It was designed to improve the bioavailability of raloxifene and provide sustained antiestrogenic blockade in the treatment of. Anaerobic biodesulfurization of thiophenes wur edepot. Highly efficient benzothiophene capture with a metal.
The birch reductions of benzothiophene and dibenzothiophene have been studied for a number of years. Mar 31, 2017 new benzothiophene derivatives as dual cox12 and 5lox inhibitors. Wandeln sie ppt oder pptxdateien schnell in ein pdfdokument um. The synthesis of these important molecules can be achieved by construction of one or both rings, or via direct functionalization of the benzothiophene core 9,10,11. Files are available under licenses specified on their description page. New benzothiophene derivatives as dual cox12 and 5lox inhibitors. Erfahre, wie du mit adobe acrobat dc eine ppt in eine pdf datei. In the present research manuscript, we described a series of new compounds containing coumarins, pyrimidines and pyrazole substituted benzothiophene derivatives 3af, 4, 5, and 7 have been synthesized from 2,4diflurobenzonitrile and methyl thioglycolate as starting material. Synthesis and antimicrobial activities of benzothiophene derivatives article pdf available in journal of the chilean chemical society 571. The reaction proceeded under mild conditions to produce useful benzothiophene and indole derivatives. High resolution image download ms powerpoint slide.
A benzothiophene in which the benzene ring is fused to the thiophene ring across positions 3 and 4. Ppt thiophene powerpoint presentation free to view. Ppt benzothiophene powerpoint presentation free to view. Oct 22, 1985 a solution of the benzothiophene ester 0. Osteoporosis is a progressive systemic skeletal disease characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. A free powerpoint ppt presentation displayed as a flash slide show on id. Predominant antagonism of 5ht 2a receptors with a lesser degree antagonism of dopamine d 2 receptors has efficacy against negative symptoms esp. Dibenzothiophene is a mancude organic heterotricyclic parent that consists of a thiophene ring flanked by two benzene rings orthofused across the 2,3 and 4,5positions. After a short initiation period of about 5 minutes, hydrogen gas was seen to be evolved and. Its various derivatives are useful as pesticides, fungicides, and herbicides. In a longterm study, arzoxifene at oral doses of 0. The present paper investigates the oxidation of benzothiophene bt, dibenzothiophene dbt, and 4methyldibenzothiophene 4mdbt by ferratevi. Thiophene is a fivemembered, sulfurcontaining heteroaromatic ring commonly used as a building block in drugs. Introduction to the compound bazedoxifene acetate way140424.
Mar 20, 2017 the synthesis of these important molecules can be achieved by construction of one or both rings, or via direct functionalization of the benzothiophene core 9,10,11. Soluble in ethanol, soluble in ether, acetone and general organic solvents, insoluble in water. Benzothiophene is an aromatic organic compound with a molecular formula c 8 h 6 s and an odor similar to naphthalene mothballs. Kinetic investigation into the photochemical oxidation of benzothiophene in seawater showed that photooxidation rates of benzothiophene were influenced by the medium, ph, heavy metal ion, dissolved oxygen, and light intensity. A ftir study of the adsorption of indole, carbazole. Ppt benzothiophene powerpoint presentation free to.
Instantly convert text documents, presentations, spreadsheets and images to pdf format with this free online pdf converter. The presence of high amounts of sulfur in soils adjacent to the study area was reported by fernandez et al. Benzothiophene carboxylate derivatives as novel allosteric. Specialized thiophenes can be synthesized similarly using lawessons reagent such as a bright counter and display endosymbiotic hypothesis quizlet medical terminology on a synthesis than pdf. Under print quality paper pdf, set the desired quality to an option of your choice. Different substitution patterns in these heterocycles provide new opportunities for. Very general involves the dehydration of 1,4dicarbonyl compounds. Kostenloser pptzupdfconverter online ppt zu pdf konvertieren. When the conversion is done, your ppt, pptx, and pdf files will be automatically deleted. Convert and create pdf from various types of files like word doc, excel xls, powerpoint ppt. Mochten sie ihre ppt zu einer pdfdatei konvertieren. Moreover, bt2related benzothiophene hydroxamic acids are botulinum nerotoxin serotype a protease inhibitors.
Powerpoint in pdf umwandeln kostenloses online tool. After a short initiation period of about 5 minutes, hydrogen gas was seen to be evolved and the reaction temperature began to rise rapidly. This free online converter allows to convert various file formats doc, docx, xls, ppt, jpg, png. Follow these instructions to set the print quality of the pdf. For the desulfurization of benzothiophene bt two different parallel reactions with h2 are. Oxidation of benzothiophene, dibenzothiophene, and methyl. All structured data from the file and property namespaces is available under the creative commons cc0 license. Kt462, which can grow on either benzothiophene bt or dibenzothiophene dbt as the sole source of sulfur, was newly isolated and characterized. Furan, thiophene and pyrrole are aromatic by virtue of their planarity and the uninterrupted. New benzothiophene derivatives as dual cox12 and 5lox. The lonepair electrons of the nitrogen atom cause amines to react as bases, sharing the lone pair with a proton, and as nucleophiles, sharing the lone pair with an atom other than a proton. In summary, we have developed an expedient route for the construction of benzothiophene and indole derivatives via propargylallene rearrangement and allyl migration. Predicted data is generated using the us environmental protection agencys episuite.
The pyrrole ring in the indoles readily undergo subistitution reactions. Download your new pdf and save it to your computer. Synthesis and antimicrobial activity of benzothiophene. The desulfurized product of dbt produced by this strain, as well as. Pdf photocatalytic degradation of benzothiophene and.